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J Endocrinol Invest 45:10711077

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The term describes the visible facial aging that can accompany rapid, significant weight loss, characterized by: Hollowed, sunken cheeks where fullness once existed Prominent nasolabial folds (lines from nose to mouth corners) that deepen dramatically Jowl formation or worsening along the jawline Under-eye hollows and dark circles that create a tired appearance Temple hollowing that creates a gaunt, skeletal look Marionette lines extending from mouth corners downward Loose, sagging skin especially around the neck and lower face Increased wrinkles and crepiness from loss of skin elasticity According to a 2025 systematic review published in Plastic and Reconstructive Surgery , Ozempic face describes exaggerated volume loss from semaglutide therapy, resulting in advanced facial aging that has led to a measurable increase in facial restoration procedures Daneshgaran et al., 2025